Asthma and allergy share a similar and very close course, especially
through childhood. Considerable research effort has been put in
untangling these associations; however, it is now becoming obvious that
this is an exceedingly difficult task. In fact, each research
breakthrough further perplexes this picture, as we are steadily moving
toward the era of personalized medicine and we begin to appreciate that
what we thought to be a single disease, asthma, is in fact an
accumulation of distinct entities. In the context of this “syndrome,”
which is characterized by several, as of yet poorly defined endotypes
and phenotypes, the question of the link of “asthma” with allergy
probably becomes non-relevant. In this review, we will revisit this
question while putting the emphasis on the multifaceted nature of
asthma.
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